Incidence of Down Syndrome by maternal age in Chinese population

Author:

Song Yi,Jieping Song,Tianshu Zhou,Zhijun Zhang,Jingxuan Zhang,Bo Wang

Abstract

Objective: This study aims to estimate the maternal age-related risk of Down syndrome in an Asian population.Methods: We performed a retrospective data analysis including a total of 206,295 pregnant women who presented for second-trimester maternal serum screening for Down syndrome at Hubei Maternal and Child Health Hospital for the years 2008–2017. Cases were assigned to three groups: ≤26 years of age, 27–33 years of age, and ≥34 years of age. The incidence of Down Syndrome was calculated for each age group. The differences between groups were tested using the chi-square (χ2) test.Results: The incidence of Down syndrome in women ≤26 years of age, 27–33 years of age, and ≥34 years of age was 0.67‰, 0.29‰, and 2.07‰ respectively. Statistically significant difference was found between the three age groups (χ2 = 79.748, p < 0.05).Conclusion: Down syndrome rate was significantly higher in women ≥34 years of age. Younger women (≤26 years of age) had a significantly higher risk for Down’s syndrome, compared to women aged 27–33.

Funder

Health and Family Planning Commission of Hubei Province

Publisher

Frontiers Media SA

Subject

Genetics (clinical),Genetics,Molecular Medicine

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