Identification and verification of a novel epigenetic-related gene signature for predicting the prognosis of hepatocellular carcinoma
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Published:2022-11-30
Issue:
Volume:13
Page:
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ISSN:1664-8021
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Container-title:Frontiers in Genetics
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language:
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Short-container-title:Front. Genet.
Author:
Wang Chenchen,Yao Chengye,Sun Yan,Chen Jiayi,Ge Yangyang,Wang Yu,Wang Fuquan,Wang Li,Lin Yun,Yao Shanglong
Abstract
Hepatocellular carcinoma (HCC) is a common malignant tumor with a poor prognosis. Epigenetic dysregulation is now considered to be related to hepatocarcinogenesis. However, it is unclear how epigenetic-related genes (ERGs) contribute to the prognosis of HCC. In this study, we used the TCGA database to identify prognostic ERGs that were differentially expressed in HCC patients. Then, using least absolute shrinkage and selection operator (LASSO) regression analysis, a six-gene signature was constructed, and patients were divided into high- and low-risk groups. Validation was performed on HCC patients from the ICGC database. Patients in the high-risk group had a significantly lower chance of survival than those in the low-risk group (p < 0.001 in both databases). The predictive ability of the signature was determined by the receiver operating characteristic (ROC) curve. The risk score was then shown to be an independent prognostic factor for the overall survival (OS) of HCC patients based on the results of univariate and multivariate analyses. We also created a practical nomogram combining the prognostic model with other clinical features. Moreover, functional enrichment analysis revealed that these genes are linked to tumor immunity. In conclusion, our findings showed that a novel six-gene signature related to epigenetics can accurately predict the occurrence and prognosis of HCC.
Publisher
Frontiers Media SA
Subject
Genetics (clinical),Genetics,Molecular Medicine
Reference47 articles.
1. The epigenetic implication in coronavirus infection and therapy;Atlante;Clin. Epigenetics,2020
2. Perceptions of epigenetics;Bird;Nature,2007
3. Cbx2 , a PcG family gene, plays a regulatory role in medaka gonadal development;Chao;Int. J. Mol. Sci.,2020
4. Discovery of nanomolar-affinity pharmacological chaperones stabilizing the oncogenic p53 mutant Y220C;Clarke;ACS Pharmacol. Transl. Sci.,2022
5. What do you mean, "epigenetic;Deans;Genet. (Austin),2015