Pharmacokinetics and Metabolite Profiling of Trepibutone in Rats Using Ultra-High Performance Liquid Chromatography Combined With Hybrid Quadrupole-Orbitrap and Triple Quadrupole Mass Spectrometers

Author:

Sun Zhi,Yang Jie,Liu Liwei,Xu Yanyan,Zhou Lin,Jia Qingquan,Shi Yingying,Du Xiangyu,Kang Jian,Zuo Lihua

Funder

National Natural Science Foundation of China

Publisher

Frontiers Media SA

Subject

Pharmacology (medical),Pharmacology

Reference19 articles.

1. In vivo acrylamide exposure may cause severe toxicity to mouse oocytes through its metabolite glycidamide;Aras;PLoS One,2017

2. New Modified UPLC/tandem mass spectrometry method for determination of risperidone and its active metabolite 9-Hydroxyrisperidone in plasma: application to dose-dependent pharmacokinetic study in sprague-dawley rats;Ezzeldin;Int. J. Anal. Chem.,2017

3. Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism10011013 GlaenzelU. JinY. NuferR. LiW. SchroerK. Adam-StitahS. 10.1124/dmd.117.079574Drug Metab. Dispos2018

4. High resolution mass spectrometry-based methodologies for identification of etravirine bioactivation to reactive metabolites: in vitro and in vivo approaches;Godinho;Eur. J. Pharm. Sci.,2018

5. Drug metabolism and metabolite safety assessment in drug discovery and development;He;Expert Opin. Drug Metab. Toxicol.,2018

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3