Author:
Wang Yonghui,Hou Meihui,Kan Zhaodong,Zhang Guanghui,Li Yunxia,Zhou Lei,Wang Changfa
Abstract
Three type III secretion system (T3SS) inhibitors (compounds 5, 19, and 32) were identified by virtual screening and biological evaluation. These three compounds were evaluated against a panel of Salmonella species strains including S. enteritidis, S. typhi, S. typhimurium, S. paratyphi, and S. abortus equi, and their minimum inhibitory concentrations ranged from 1 to 53 μg/ml. Especially, these compounds showed comparable activity as the of the positive control gatifloxacin towards S. abortus equi. The present results suggest that these new T3SS inhibitors could be used as a potential lead molecule for drug development of anti-Salmonella.
Funder
National Natural Science Foundation of China
Subject
Pharmacology (medical),Pharmacology
Reference20 articles.
1. Rapid Identification of Salmonella enterica Serovars, Typhimurium, Choleraesuis, Infantis, Hadar, Enteritidis, Dublin and Gallinarum, by Multiplex PCR;Akiba;J. Microbiol. Methods,2011
2. Evolution of Chloramphenicol Resistance, with Emergence of Cross-Resistance to Florfenicol, in Bovine Salmonella Typhimurium Strains Implicates Definitive Phage Type (DT) 104;Arcangioli;J. Med. Microbiol.,2000
3. Inhibition of Salmonella Typhimurium Adhesion, Invasion, and Intracellular Survival via Treatment with Methyl Gallate Alone and in Combination with Marbofloxacin;Birhanu;Vet. Res.,2018
4. The crystal Structures of the Salmonella Type III Secretion System Tip Protein SipD in Complex with Deoxycholate and Chenodeoxycholate;Chatterjee;Protein Sci.,2011
5. The Type III Secretion Injectisome;Cornelis;Nat. Rev. Microbiol.,2006
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献