Author:
Guo Wenyi,Chen Shihong,Li Chengqing,Xu Jianwei,Wang Lei
Abstract
Disulfiram has been used clinically for decades as an anti-alcoholic drug. Recently, several studies have demonstrated the anti-inflammatory effects of disulfiram and its metabolism, which can alleviate the progression of inflammation in vivo and in vitro. In the current study, we summarize the anti-inflammatory mechanisms of disulfiram and its metabolism, including inhibition of pyroptosis by either covalently modifying gasdermin D or inactivating nod-like receptor protein 3 inflammasome, dual effects of intracellular reactive oxygen species production, and inhibition of angiogenesis. Furthermore, we review the potential application of disulfiram and its metabolism in treatment of inflammatory disorders, such as inflammatory bowel disease, inflammatory injury of kidney and liver, type 2 diabetes mellitus, sepsis, uveitis, and osteoarthritis.
Funder
Natural Science Foundation of Shandong Province
Key Technology Research and Development Program of Shandong
Subject
Pharmacology (medical),Pharmacology
Reference92 articles.
1. Alcoholic Liver Disease: Pathogenesis and New Targets for Therapy;Altamirano;Nat. Rev. Gastroenterol. Hepatol.,2011
2. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2020;Diabetes Care,2020
3. Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome;Bauernfeind;J. Immunol.,2011
4. Cancer Risk in Patients with Inflammatory Bowel Disease: a Population-Based Study;Bernstein;Cancer,2001
5. Could Honey Have a Place in Colitis Therapy? Effects of Honey, Prednisolone, and Disulfiram on Inflammation, Nitric Oxide, and Free Radical Formation;Bilsel;Dig. Surg.,2002
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献