Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses-Reference-Cited by-同舟云学术

Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses

Published:2023-03-31 Issue: Volume:14 Page:
ISSN:1663-9812
Container-title:Frontiers in Pharmacology
language:
Short-container-title:Front. Pharmacol.

Author:

Li Simin,Chen Yichang,Ma Ruolin,Du Ye,Han Bing

Abstract

Graphical AbstractThe PEG-PLGA nanoparticles effectively delivered R848 and CD47 siRNA into tumor cells, resulting in simultaneous activation of DCs and downregulation of CD47 expression on tumor cells, thereby enhancing antitumor immune responses by T cells.

Funder

Natural Science Foundation of Jilin Province

Publisher

Frontiers Media SA

Subject

Pharmacology (medical),Pharmacology

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