Author:
Yin Ruochun,Zhang Yiling,Su Liping,Chen Dongdong,Lou Shidi,Luo Xuecai,Wang Lin,Tang Rupei,Zhang Liang,Tian Xiaohe
Abstract
Trans-δ-viniferin (TVN), as a natural extract, is a resveratrol dimer with attractive biological activities, particularly its anti-tumor character. However, the mechanism of TVN interfering with cancerous proliferation has not been fully understood. Herein in this study, we found that TVN could trigger cancerous mitochondrial membrane potential (ΔΨm) reduction, with intracellular reactive oxidative species (ROS) level increasing, leading to apoptosis, which makes TVN a promising candidate for lung cancer cells A549 treatment. Therefore, this study provides TVN as an option to meet the demand for higher antitumor availability with lower biotoxicity and other clinical applications.
Subject
Pharmacology (medical),Pharmacology
Reference29 articles.
1. Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization;Baity;Am. J. Cancer Res.,2019
2. Oxidative stress to promote cell death or survival;Battistelli;Oxid. Med. Cell Longev.,2016
3. Classification, staging and prognosis of lung cancer;Beadsmoore;Eur. J. Radio,2003
4. Comprehensive review on the antimicrobial potency of the plant polyphenol resveratrol;Bostanghadiri;Biomed. Pharmacother.,2017
5. ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells;Cao;Free Radic. Bio Med.,2009