Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1

Author:

Dai Zhang’an,Cai Lin,Chen Yingyu,Wang Silu,Zhang Qian,Wang Chengde,Tu Ming,Zhu Zhangzhang,Li Qun,Lu Xianghe

Abstract

Brusatol (Bru), a Chinese herbal extract, has a variety of anti-tumor effects. However, little is known regarding its role and underlying mechanism in glioblastoma cells. Here, we found that Bru could inhibit the proliferation of glioblastoma cells in vivo and in vitro. Besides, it also had an inhibitory effect on human primary glioblastoma cells. RNA-seq analysis indicated that Bru possibly achieved these effects through inhibiting the expression of extracellular matrix protein 1 (ECM1). Down-regulating the expression of ECM1 via transfecting siRNA could weaken the proliferation and invasion of glioblastoma cells and promote the inhibitory effect of Bru treatment. Lentivirus-mediated overexpression of ECM1 could effectively reverse this weakening effect. Our findings indicated that Bru could inhibit the proliferation and invasion of glioblastoma cells by suppressing the expression of ECM1, and Bru might be a novel effective anticancer drug for glioblastoma cells.

Funder

Wenzhou Municipal Science and Technology Bureau

Medical Scientific Research Foundation of Zhejiang Province, China

Natural Science Foundation of Zhejiang Province

Publisher

Frontiers Media SA

Subject

Pharmacology (medical),Pharmacology

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