Anti-hyperuricemia effect of hesperetin is mediated by inhibiting the activity of xanthine oxidase and promoting excretion of uric acid-Reference-Cited by-同舟云学术

Anti-hyperuricemia effect of hesperetin is mediated by inhibiting the activity of xanthine oxidase and promoting excretion of uric acid

Published:2023-04-12 Issue: Volume:14 Page:
ISSN:1663-9812
Container-title:Frontiers in Pharmacology
language:
Short-container-title:Front. Pharmacol.

Author:

An Meng-Fei,Shen Chang,Zhang Shao-Shi,Wang Ming-Yue,Sun Ze-Rui,Fan Mao-Si,Zhang Li-Juan,Zhao Yun-Li,Sheng Jun,Wang Xuan-Jun

Abstract

Graphical AbstractBoth in vivo and in vitro experiments suggested that HSE may effectively lower uric acid. The mechanism might be the inhibition of XOD activity, down-regulation of TLR4-NLRP3 inflammasome and up-regulation expression of OAT1, OAT3, OCT1, OCT2 proteins.

Funder

Yunnan Provincial Department of Education

Major Science and Technology Projects in Yunnan Province

National Natural Science Foundation of China

Publisher

Frontiers Media SA

Subject

Pharmacology (medical),Pharmacology

Reference63 articles.

1. Assay systems for screening food and natural substances that have anti-hyperuricemic activity: Uric acid production in cultured hepatocytes and purine bodies-induced hyperuricemic model mice;Adachi;Cytotechnology,2017

2. Prevalence of hyperuricemia and the relationship between serum uric acid and obesity: A study on Bangladeshi adults;Ali;PLoS One,2018

3. Isoorientin exerts a urate-lowering effect through inhibition of xanthine oxidase and regulation of the TLR4-NLRP3 inflammasome signaling pathway;An;J. Nat. Med.,2021