Author:
Tian Liang,Huang Chongfei,Fu Wenkang,Gao Long,Mi Ningning,Bai Mingzhen,Ma Haidong,Zhang Chao,Lu Yawen,Zhao Jinyu,Zhang Xianzhuo,Jiang Ningzu,Lin Yanyan,Yue Ping,Yuan Jinqiu,Meng Wenbo
Abstract
Proton pump inhibitors (PPIs) are the most used acid-inhibitory drugs, with a wide range of applications in the treatment of various digestive diseases. However, recently, there has been a growing number of digestive complications linked to PPIs, and several studies have indicated that the intestinal flora play an important role in these complications. Therefore, developing a greater understanding of the role of the gut microbiota in PPI-related digestive diseases is essential. Here, we summarize the current research on the correlation between PPI-related digestive disorders and intestinal flora and establish the altered strains and possible pathogenic mechanisms of the different diseases. We aimed to provide a theoretical basis and reference for the future treatment and prevention of PPI-related digestive complications based on the regulation of the intestinal microbiota.
Subject
Pharmacology (medical),Pharmacology
Reference122 articles.
1. Small intestinal bacterial overgrowth: Nutritional implications, diagnosis, and management;Adike;Gastroenterol. Clin. North Am.,2018
2. Increasing incidence of clostridium difficile-associated diarrhea in african-American and hispanic patients: Association with the use of proton pump inhibitor therapy;Akhtar;J. Natl. Med. Assoc.,2007
3. Proton pump inhibitor use: A risk factor for inflammatory bowel disease or an innocent bystander?;Allin;Gastroenterology,2021
4. Escherichia coli challenge and one type of smectite alter intestinal barrier of pigs;Almeida;J. Anim. Sci. Biotechnol.,2013
5. Bile acids: Major regulator of the gut microbiome;An;Microorganisms,2022
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