Insights Into Amentoflavone: A Natural Multifunctional Biflavonoid

Author:

Xiong Xifeng,Tang Nan,Lai Xudong,Zhang Jinli,Wen Weilun,Li Xiaojian,Li Aiguo,Wu Yanhua,Liu Zhihe

Abstract

Amentoflavone is an active phenolic compound isolated from Selaginella tamariscina over 40 years. Amentoflavone has been extensively recorded as a molecule which displays multifunctional biological activities. Especially, amentoflavone involves in anti-cancer activity by mediating various signaling pathways such as extracellular signal-regulated kinase (ERK), nuclear factor kappa-B (NF-κB) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), and emerges anti-SARS-CoV-2 effect via binding towards the main protease (Mpro/3CLpro), spike protein receptor binding domain (RBD) and RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Therefore, amentoflavone is considered to be a promising therapeutic agent for clinical research. Considering the multifunction of amentoflavone, the current review comprehensively discuss the chemistry, the progress in its diverse biological activities, including anti-inflammatory, anti-oxidation, anti-microorganism, metabolism regulation, neuroprotection, radioprotection, musculoskeletal protection and antidepressant, specially the fascinating role against various types of cancers. In addition, the bioavailability and drug delivery of amentoflavone, the molecular mechanisms underlying the activities of amentoflavone, the molecular docking simulation of amentoflavone through in silico approach and anti-SARS-CoV-2 effect of amentoflavone are discussed.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Traditional Chinese Medicine Bureau of Guangdong Province

Guangzhou Municipal Science and Technology Project

Guangzhou Municipal Health and Family Planning Commission

Publisher

Frontiers Media SA

Subject

Pharmacology (medical),Pharmacology

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