Author:
Gao Han,He Chengwei,Hua Rongxuan,Liang Chen,Wang Boya,Du Yixuan,Xin Shuzi,Guo Yuexin,Gao Lei,Zhang Lucia,Shang Hongwei,Xu Jingdong
Abstract
Graphical Abstract1. Constipation leads to the enhanced thickness of muscle layer and sedimentation of collagenous fiber. 2. Constipation promotes not only the pro-inflammtory cytokines secretion but also damage the integrity of intestinal barrier. 3. The present results are significant in at least two major respects in the alternations of the diversity of gut microbiome along with the fluctuation of the fatty acid and bioamine in constipation mice. 4. One unanticipated finding is that the rhubarb extract has the potential to reverse the alterations induced by constipation.
Funder
National Natural Science Foundation of China
Subject
Pharmacology (medical),Pharmacology
Cited by
2 articles.
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