Author:
Yu Zhu,Cao Wenlong,Han Chuangye,Wang Zhen,Qiu Yue,Wang Jiancheng,Wei Mengda,Wang Junfu,Zhang Siwen,Liu Senfeng,Mo Shutian,Chen Junqiang
Abstract
In recent years, sonodynamic therapy (SDT) has been widely developed for cancer research as a promising non-invasive therapeutic strategy. Here, we synthesized zeolitic imidazole frameworks-8 (ZIF-8) and utilized its properties to encapsulate hydrophobic Chlorin e6 (Ce6) and hydrophilic tirapazamine (TPZ) for a synergistic sonodynamic chemotherapy, which was also accompanied by the modification of cytomembrane of gastric cancer (GC) cells. Thus, we enabled the biomimetic property to achieve targeted delivery. Ce6-mediated SDT, in combination with ultrasound irradiation, could target the release of reactive oxygen species (ROS) to aggravate further hypoxia and activate TPZ. Combining these effects could induce the pyroptosis of GC cells and play the anti-tumor function, which could provide a potential therapeutic method for cancer therapy.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangxi Province
Guangxi Key Research and Development Program
Scientific Research and Technology Development Program of Guangxi
Science and Technology Major Project of Guangxi
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献