Author:
Jiang Tianyue,Liu Chendan,Xu Xiao,He Bingfang,Mo Ran
Abstract
Exploiting enzyme-catalyzed reactions to manipulate molecular assembly has been considered as an attractive bottom-up nanofabrication approach to developing a variety of nano-, micro-, and macroscale structures. Upon enzymatic catalysis, peptides and their derivatives transform to assemblable building blocks that form ordered architecture by non-covalent interactions. The peptide assemblies with unique characteristics have great potential for applications in bionanotechnology and biomedicine. In this mini review, we describe typical mechanisms of the protease-instructed peptide assembly via bond-cleaving or bond-forming reactions, and outline biomedical applications of the peptide assemblies, such as drug depot, sustained release, controlled release, gelation-regulated cytotoxicity, and matrix construction.
Funder
National Basic Research Program of China
National Natural Science Foundation of China
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Cited by
3 articles.
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