Author:
Slavin Benjamin R.,Sarhane Karim A.,von Guionneau Nicholas,Hanwright Phillip J.,Qiu Chenhu,Mao Hai-Quan,Höke Ahmet,Tuffaha Sami H.
Abstract
Patients who sustain peripheral nerve injuries (PNIs) are often left with debilitating sensory and motor loss. Presently, there is a lack of clinically available therapeutics that can be given as an adjunct to surgical repair to enhance the regenerative process. Insulin-like growth factor-1 (IGF-1) represents a promising therapeutic target to meet this need, given its well-described trophic and anti-apoptotic effects on neurons, Schwann cells (SCs), and myocytes. Here, we review the literature regarding the therapeutic potential of IGF-1 in PNI. We appraised the literature for the various approaches of IGF-1 administration with the aim of identifying which are the most promising in offering a pathway toward clinical application. We also sought to determine the optimal reported dosage ranges for the various delivery approaches that have been investigated.
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Cited by
19 articles.
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