Author:
Xu Zhong-jie,Zhou Ying-jie,Wang Jia-hao,Mao Long-fei,Li Wei,Xu Gui-qing
Abstract
In this study, acenaphthylene was used as the raw material, and a series of novel 1,8-naphthalimide-1,2,3-triazole derivatives was obtained through oxidation, acylation, alkylation, and click reactions, and subsequently, their anti-tumor activities were tested. After screening, we found that Compound 5e showed good activity against H1975 lung cancer cells, with the half maximal inhibitory concentration (IC50) reaching 16.56 μM.
Funder
Key Scientific Research Project of Colleges and Universities in Henan Province
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
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