Author:
Li Caiyun,Alam Khorshed,Zhao Yiming,Hao Jinfang,Yang Qing,Zhang Youming,Li Ruijuan,Li Aiying
Abstract
Antimicrobial resistance is one of the most serious public health issues in the worldwide and only a few new antimicrobial drugs have been discovered in recent decades. To overcome the ever-increasing emergence of multidrug-resistant (MDR) pathogens, discovery of new natural products (NPs) against MDR pathogens with new technologies is in great demands. Lanthipeptides which are ribosomally synthesized and post-translationally modified peptides (RiPPs) display high diversity in their chemical structures and mechanisms of action. Genome mining and biosynthetic engineering have also yielded new lanthipeptides, which are a valuable source of drug candidates. In this review we cover the recent advances in the field of microbial derived lanthipeptide discovery and development.
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Cited by
15 articles.
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