Author:
Luo Tianyi,Tan Bowen,Zhu Lengjing,Wang Yating,Liao Jinfeng
Abstract
Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility. Especially, the stiffness of hydrogels is a key factor, which influence the morphology of mesenchymal stem cells (MSCs) and their differentiation. The researches on this point are meaningful to the field of tissue engineering. Herein, this review focus on the design of hydrogels with different stiffness and their effects on the behavior of MSCs. In addition, the effect of hydrogel stiffness on the phenotype of macrophages is introduced, and then the relationship between the phenotype changes of macrophages on inflammatory response and tissue repair is discussed. Finally, the future application of hydrogels with a certain stiffness in regenerative medicine and tissue engineering has been prospected.
Funder
National Natural Science Foundation of China
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Reference179 articles.
1. Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering;Abalymov;Polymers,2020
2. Influence of Hydrolyzed Polyacrylamide Hydrogel Stiffness on Podocyte Morphology, Phenotype, and Mechanical Properties;Abdallah;ACS Appl. Mater. Inter.,2019
3. Temporal Modulation of Stem Cell Activity Using Magnetoactive Hydrogels;Abdeen;Adv. Healthc. Mater.,2016
4. Cutting-edge Progress and Challenges in Stimuli Responsive Hydrogel Microenvironment for success in Tissue Engineering Today;Abdollahiyan;J. Controlled Release,2020
5. Hydrogel‐Based 3D Bioprinting for Bone and Cartilage Tissue Engineering;Abdollahiyan;Biotechnol. J.,2020
Cited by
36 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献