Author:
Liu Xin-Xin,Zhang Bin,Ai Lian-Zhong
Abstract
5-Hydroxytryptophan (5-HTP) plays an important role in the regulation of emotion, behavior, sleep, pain, body temperature, and other physiological functions. It is used in the treatment of depression, insomnia, migraine, and other diseases. Due to a lack of effective biosynthesis methods, 5-HTP is mainly obtained by natural extraction, which has been unable to meet the needs of the market. Through the directed evolution of enzymes and the introduction of substrate supply pathways, 5-HTP biosynthesis and yield increase have been realized. This review provides examples that illustrate the production mode of 5-HTP and the latest progress in microbial synthesis.
Funder
National Natural Science Foundation of China
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Reference49 articles.
1. Local production of 5-HTP from the seeds of Griffonia simplicifolia;Addotey;World J. Pharm. Pharm,2009
2. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo;Benedittis;J. Neurosurg. Sci.,1985
3. 5-Hydroxytryptophan: a clinically-effective serotonin precursor;Birdsall;Altern. Med. Rev,1998
4. Serotonin precursors in migraine prophylaxis;Bono;Adv. Neurol,1982
5. Effects of 5-Hydroxytryptophan on Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献