Author:
Shakir Shahad,Hackett Tillie Louise,Mostaço-Guidolin Leila B.
Abstract
Chronic respiratory diseases remain a significant health burden worldwide. The only option for individuals with end-stage lung failure remains Lung Transplantation. However, suitable organ donor shortages and immune rejection following transplantation remain a challenge. Since alternative options are urgently required to increase tissue availability for lung transplantation, researchers have been exploring lung bioengineering extensively, to generate functional, transplantable organs and tissue. Additionally, the development of physiologically-relevant artificial tissue models for testing novel therapies also represents an important step toward finding a definite clinical solution for different chronic respiratory diseases. This mini-review aims to highlight some of the most common methodologies used in bioengineering lung scaffolds, as well as the benefits and disadvantages associated with each method in conjunction with the current areas of research devoted to solving some of these challenges in the area of lung bioengineering.
Funder
Natural Sciences and Engineering Research Council of Canada
Subject
Biomedical Engineering,Histology,Bioengineering,Biotechnology
Reference85 articles.
1. The effects of plasma treated electrospun nanofibrous poly (ε-caprolactone) scaffolds with different orientations on mouse embryonic stem cell proliferation;Abbasi;Cell. J.,2014
2. Induced pluripotent stem cells (iPSCs)—roles in regenerative therapies, disease modelling and drug screening;Aboul-Soud;Cells,2021
3. Recellularization of native tissue derived acellular scaffolds with mesenchymal stem cells;Ahmed;Cells,2021
4. Cell-based tissue engineering for lung regeneration;Andrade;Am. J. Physiology-Lung Cell. Mol. Physiology,2007
5. Fabrication and plasma modification of nanofibrous tissue engineering scaffolds;Asadian;Nanomater. (Basel, Switz.,2020
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