Author:
Ferrer-Fàbrega Joana,Mesnard Benoît,Messner Franka,Doppenberg Jason B.,Drachenberg Cinthia,Engelse Marten A.,Johnson Paul R. V.,Leuvenink Henri G. D.,Oniscu Gabriel C.,Papalois Vassilios,Ploeg Rutger J.,Reichman Trevor W.,Scott William E,Vistoli Fabio,Berney Thierry,Jacobs-Tulleneers-Thevissen Daniel,Kessaris Nicos,Weissenbacher Annemarie,Ogbemudia Ann Etohan,White Steve,Branchereau Julien
Abstract
The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidney’s and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the “Role of pancreas machine perfusion to increase the donor pool for beta cell replacement,” the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague.