Author:
Flores-Lujano Janet,Duarte-Rodríguez David Aldebarán,Jiménez-Hernández Elva,Martín-Trejo Jorge Alfonso,Allende-López Aldo,Peñaloza-González José Gabriel,Pérez-Saldivar María Luisa,Medina-Sanson Aurora,Torres-Nava José Refugio,Solís-Labastida Karina Anastacia,Flores-Villegas Luz Victoria,Espinosa-Elizondo Rosa Martha,Amador-Sánchez Raquel,Velázquez-Aviña Martha Margarita,Merino-Pasaye Laura Elizabeth,Núñez-Villegas Nora Nancy,González-Ávila Ana Itamar,del Campo-Martínez María de los Ángeles,Alvarado-Ibarra Martha,Bekker-Méndez Vilma Carolina,Cárdenas-Cardos Rocío,Jiménez-Morales Silvia,Rivera-Luna Roberto,Rosas-Vargas Haydee,López-Santiago Norma C.,Rangel-López Angélica,Hidalgo-Miranda Alfredo,Vega Elizabeth,Mata-Rocha Minerva,Sepúlveda-Robles Omar Alejandro,Arellano-Galindo José,Núñez-Enríquez Juan Carlos,Mejía-Aranguré Juan Manuel
Abstract
IntroductionOver the years, the Hispanic population living in the United States has consistently shown high incidence rates of childhood acute leukemias (AL). Similarly, high AL incidence was previously observed in Mexico City (MC). Here, we estimated the AL incidence rates among children under 15 years of age in MC during the period 2010–2017.MethodsThe Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia conducted a study gathering clinical and epidemiological information regarding children newly diagnosed with AL at public health institutions of MC. Crude age incidence rates (cAIR) were obtained. Age-standardized incidence rates worldwide (ASIRw) and by municipalities (ASIRm) were calculated by the direct and indirect methods, respectively. These were reported per million population <15 years of age; stratified by age group, sex, AL subtypes, immunophenotype and gene rearrangements.ResultsA total of 903 AL cases were registered. The ASIRw was 63.3 (cases per million) for AL, 53.1 for acute lymphoblastic leukemia (ALL), and 9.4 for acute myeloblastic leukemia. The highest cAIR for AL was observed in the age group between 1 and 4 years (male: 102.34 and female: 82.73). By immunophenotype, the ASIRw was 47.3 for B-cell and 3.7 for T-cell. The incidence did not show any significant trends during the study period. The ASIRm for ALL were 68.6, 66.6 and 62.8 at Iztacalco, Venustiano Carranza and Benito Juárez, respectively, whereas, other municipalities exhibited null values mainly for AML.ConclusionThe ASIRw for childhood AL in MC is among the highest reported worldwide. We observed spatial heterogeneity of rates by municipalities. The elevated AL incidence observed in Mexican children may be explained by a combination of genetic background and exposure to environmental risk factors.
Funder
Consejo Nacional de Ciencia y Tecnología
Instituto Mexicano del Seguro Social
Secretaría de Educación Superior, Ciencia, Tecnología e Innovación
Instituto Nacional de Medicina Genómica
Subject
Public Health, Environmental and Occupational Health
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献