Author:
Lin Yu-Jung,Chen Hsin-Chang,Chang Jung-Wei,Huang Han-Bin,Chang Wan-Ting,Huang Po-Chin
Abstract
IntroductionEver since the use of bisphenol A (BPA) has been restricted, concerns have been raised regarding the use of its substitutes, such as bisphenol S (BPS) and bisphenol F (BPF). Meanwhile, the EU European Food Safety Authority (EFSA) issued the new tolerable daily intake (TDI) after the latest re-risk assessment for BPA, which enforced the need for cumulative risk assessment in the population. This study was conducted to identify BPA and its substitute’s exposure characteristics of the general Taiwanese population and estimate the cumulative risk of bisphenol exposure.MethodsUrine samples (N = 366 [adult, 271; minor, 95]) were collected from individuals who participated in the Taiwan Environmental Survey for Toxicants 2013. The samples were analyzed for BPA, BPS, and BPF through ultraperformance liquid chromatography–tandem mass spectrometry. Daily intake (DI) levels were calculated for each bisphenol. Hazard quotients (HQs) were calculated with the consideration of tolerable DI and a reference dose. Additionally, hazard index (HI; sum of HQs for each bisphenol) values were calculated.ResultsOur study found that the median level of BPA was significantly higher in adults (9.63 μg/g creatinine) than in minors (6.63 μg/g creatinine) (p < 0.001). The DI of BPS was higher in female (0.69 ng/kg/day) than in male (0.49 ng/kg/day); however, the DIs of BPF and BPS were higher in boys (1.15 and 0.26 ng/kg/day, respectively) than in girls (0.57 and 0.20 ng/kg/day, respectively). Most HI values exceeded 1 (99% of the participants) after EFSA re-establish the TDI of BPA.DiscussionOur study revealed that the exposure profiles and risk of BPA and its substitute in Taiwanese varied by age and sex. Additionally, the exposure risk of BPA was deemed unacceptable in Taiwan according to new EFSA regulations, and food contamination could be the possible source of exposure. We suggest that the risk of exposure to BPA and its substitutes in most human biomonitoring studies should be reassessed based on new scientific evidence.
Reference107 articles.
1. The mixture effects of bisphenol derivatives on estrogen receptor and androgen receptor;Park;Environ Pollut,2020
2. An overview of the occurrence, fate, and human risks of the bisphenol-a present in plastic materials, components, and products;Hahladakis;Integr Environ Assess Manag,2022
3. Bisphenol a and its substitutes in the aquatic environment: occurrence and toxicity assessment;Czarny-Krzymińska;Chemosphere,2023
4. Phthalate and BPA exposure in women and newborns through personal care product use and food packaging;Fisher;Environ Sci Technol,2019
5. Urinary levels of phthalate, bisphenol, and paraben and allergic outcomes in children: Korean National Environmental Health survey 2015–2017;Hwang;Sci Total Environ,2022