Therapeutic Prospects of Polysaccharides for Ovarian Cancer

Author:

Wang Kaili,Cai Mengcheng,Sun Shuai,Cheng Wen,Zhai Dongxia,Ni Zhexin,Yu Chaoqin

Abstract

Ovarian cancer (OC) is ranked as the leading cause of death among cancers of the female reproductive tract. First-line platinum treatment faces the severe challenges associated with the patient relapse and poor prognosis. Thus, it is imperative to develop natural antitumor drugs for OC with high efficacy. Natural polysaccharides have significant biological activities and antitumor effects. Our work has demonstrated that polysaccharides play key roles by inhibiting the cell proliferation and growth, regulating the tumor cell cycle, inducing apoptosis, suppressing the tumor cell migration and invasion, improving the immunomodulatory activities, and enhancing the efficacy of chemotherapy (cisplatin) in OC, which provide powerful evidence for the application of polysaccharides as novel anticancer agents, supplementary remedies, and adjunct therapeutic agents alone or in combination with cisplatin for preventing and treating the OC.

Publisher

Frontiers Media SA

Subject

Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Food Science

Reference47 articles.

1. Ovarian cancer;Matulonis;Nat Rev Dis Primers.,2016

2. Epigenetics in ovarian cancer;Natanzon;Semin Cancer Biol.,2018

3. Cancer statistics 2019;Siegel;CA Cancer J Clin,2019

4. Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer;Zhang;Biochim Biophys Acta Rev Cancer.,2021

5. ATR-FTIR spectroscopy shows changes in ovarian cancer cells after incubation with novel organoamidoplatinum(ii) complexes;Al-Jorani;Analyst.,2018

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