Author:
Morales Eva,García-Serna Azahara M.,Larqué Elvira,Sánchez-Campillo María,Serrano-Munera Ana,Martinez-Graciá Carmen,Santaella-Pascual Marina,Suárez-Martínez Clara,Vioque Jesús,Noguera-Velasco José A.,Avilés-Plaza Francisco V.,Martínez-Villanueva Miriam,Ballesteros-Meseguer Carmen,Galdo-Castiñeira Lina,García-Marcos Luis
Abstract
BackgroundAlthough adherence to the Mediterranean and antioxidant-rich diets during pregnancy is suggested to improve maternal-fetal health by reducing oxidative stress, yet there is no study available.ObjectiveWe examined whether maternal dietary patterns in pregnancy impact the biomarkers of oxidative stress in mothers and their offspring.MethodsStudy population included 642 mothers and 335 newborns of the “Nutrition in Early Life and Asthma” (NELA) birth cohort. Maternal diet during pregnancy was assessed by a validated food frequency questionnaire and a priori-defined dietary indices (relative Mediterranean Diet [rMED], alternative Mediterranean Diet [aMED], Dietary Approach to Stop Hypertension [DASH], Alternate Healthy Index [AHEI], and AHEI-2010) were calculated. Biomarkers measured were: hydroperoxides, carbonyl groups, and 8-hydroxydeoxyguanosine (8OHdG) determined in maternal blood and newborn cord blood, and urinary maternal and offspring 15-F2t-isoprostane. Multivariate linear regression models were performed.ResultsMaternal rMED score was inversely associated with the maternal levels of 8OHdG at mid-pregnancy (beta per 1-point increase = −1.61; 95% CI −2.82, −0.39) and the newborn levels of hydroperoxides (beta per 1-point increase = −4.54; 95% CI −9.32, 0.25). High vs. low maternal rMED score was marginally associated with the decreased levels of 8OHdG in newborns (beta = −9.17; 95% CI −19.9, 1.63; p for trend 0.079). Maternal DASH score tended to be inversely associated with maternal urinary 15-F2t-isoprostane (beta per 1-point increase = −0.69; 95% CI, −1.44, 0.06). High vs. low maternal AHEI score was associated with reduced offspring urinary levels of 15-F2t-isoprostane (beta = −20.2; 95% CI −38.0, −2.46; p for trend 0.026).ConclusionThese results suggest that maternal adherence to healthy dietary patterns during pregnancy may reduce DNA damage and lipid oxidation in mothers and offspring.
Funder
Instituto de Salud Carlos III
Subject
Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Food Science
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献