Xylitol-Containing Chewing Gum Reduces Cariogenic and Periodontopathic Bacteria in Dental Plaque—Microbiome Investigation

Author:

Wu Yi-Fan,Salamanca Eisner,Chen I-Wen,Su Jo-Ning,Chen Yu-Che,Wang Sin Yu,Sun Ying-Sui,Teng Nai-Chia,Chang Wei-Jen

Abstract

BackgroundDental caries and periodontal disease remain the most prevalent oral health problems in the world. Chewing xylitol gum may help reduce the risk of caries and periodontitis for dental health benefits. However, little evidence has shown healthy food estimation by sequencing 16S rDNA in oral microbial communities. This study investigated the clinical effect of xylitol chewing gum on dental plaque accumulation and microbiota composition using the PacBio full-length sequencing platform in 24 young adults (N = 24). The participants were randomly assigned to xylitol chewing gum and control (no chewing gum) groups. Participants in the chewing gum group chewed ten pieces of gum (a total of 6.2 g xylitol/day). Dental plaque from all teeth was collected for weighing, measuring the pH value, and analysis of microbial communities at the beginning (baseline, M0) and end of the 2-week (effect, M1) study period.ResultsThe results suggested a 20% reduction in dental plaque accumulation (p < 0.05) among participants chewing xylitol gum for 2 weeks, and the relative abundance of Firmicutes (a type of pathogenic bacteria associated with caries) decreased by 10.26% (p < 0.05) and that of Bacteroidetes and Actinobacteria (two types of pathogenic bacteria associated with periodontitis) decreased by 6.32% (p < 0.001) and 1.66% (p < 0.05), respectively. Moreover, the relative abundance of Fusobacteria was increased by 9.24% (p < 0.001), which has been proven to have a higher proportion in dental plaque of healthy adults. However, the dental plaque pH value stayed in a healthy range for the two groups.ConclusionIn conclusion, chewing xylitol gum would benefit cariogenic and periodontal bacterial reduction in the oral cavity, which could help to prevent the diseases related to these bacteria.

Publisher

Frontiers Media SA

Subject

Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Food Science

Reference51 articles.

1. The world oral health report 2003: continuous improvement of oral health in the 21st century–the approach of the who global oral health programme.;Petersen;Commun Dent Oral Epidemiol.,2003

2. Dental caries: an update on dental trends and therapy.;Wong;Adv Pediatr.,2017

3. Dental caries: a microbiological approach.;Yadav;J Clin Infect Dis Pract.,2017

4. The microbiology of primary dental caries in humans.;Tanzer;J Dent Educ.,2001

5. Three clinical trials comparing xylitol-and sorbitol-containing chewing gums for their effect on supragingival plaque accumulation.;Cronin;J Clin Dent.,1994

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