Distributed Functional Connectome of White Matter in Patients With Functional Dyspepsia
-
Published:2021-04-16
Issue:
Volume:15
Page:
-
ISSN:1662-5161
-
Container-title:Frontiers in Human Neuroscience
-
language:
-
Short-container-title:Front. Hum. Neurosci.
Author:
Xu Qiang,Weng Yifei,Liu Chang,Qiu Lianli,Yang Yulin,Zhou Yifei,Wang Fangyu,Lu Guangming,Zhang Long Jiang,Qi Rongfeng
Abstract
Purpose: We aimed to find out the distributed functional connectome of white matter in patients with functional dyspepsia (FD).Methods: 20 patients with FD and 24 age- and gender-matched healthy controls were included into the study. The functional connectome of white matter and graph theory were used to these participants. Two-sample t-test was used for the detection the abnormal graph properties in FD. Pearson correlation was used for the relationship between properties and the clinical and neuropshychological information.Results: Patients with FD and healthy controls showed small-world properties in functional connectome of white matter. Compared with healthy controls, the FD group showed decreased global properties (Cp, S, Eglobal, and Elocal). Four pairs of fiber bundles that are connected to the frontal lobe, insula, and thalamus were affected in the FD group. Duration and Pittsburgh Sleep Quality Index positively correlated with the betweenness centrality of white matter regions of interest.Conclusion: FD patients turned to a non-optimized functional organization of WM brain network. Frontal lobe, insula, and thalamus were key regions in brain information exchange of FD. It provided some novel imaging evidences for the mechanism of FD.
Funder
National Natural Science Foundation of China
Jiangsu Provincial Medical Youth Talent
China Postdoctoral Science Foundation
Jiangsu Province Postdoctoral Science Foundation
Ministry of Science and Technology, Government of the People‘s Republic of Bangladesh
Publisher
Frontiers Media SA
Subject
Behavioral Neuroscience,Biological Psychiatry,Psychiatry and Mental health,Neurology,Neuropsychology and Physiological Psychology
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献