Increased Phase Cone Turnover in 80–250 Hz Bands Occurs in the Epileptogenic Zone During Interictal Periods

Abstract

We found that phase cone clustering patterns in EEG ripple bands demonstrate an increased turnover rate in epileptogenic zones compared to adjacent regions. We employed 256 channel EEG data collected in four adult subjects with refractory epilepsy. The analysis was performed in the 80–150 and 150–250 Hz ranges. Ictal onsets were documented with intracranial EEG recordings. Interictal scalp recordings, free of epileptiform patterns, of 240-s duration, were selected for analysis for each subject. The data was filtered, and the instantaneous phase was extracted after the Hilbert transformation. Spatiotemporal contour plots of the unwrapped instantaneous phase with 1.0 ms intervals were constructed using a montage layout of the 256 electrode positions. Stable phase cone patterns were selected based on criteria that the sign of spatial gradient did not change for a minimum of three consecutive time samples and the frame velocity was consistent with known propagation velocities of cortical axons. These plots exhibited increased dynamical formation and dissolution of phase cones in the ictal onset zones, compared to surrounding cortical regions, in all four patients. We believe that these findings represent markers of abnormally increased cortical excitability. They are potential tools that may assist in localizing the epileptogenic zone.