Author:
Pinto Raquel,Magalhães Ana,Sousa Mafalda,Melo Lúcia,Lobo Andrea,Barros Pedro,Gomes João R.
Abstract
Graphical AbstractImproving translation of tMCAO mice model. Improvement of the surgical procedure, post-operative care and functional evaluation in the tMCAO mice, gives rise to a model with high parallel and translation into clinical reality. Induction of ischemia for 45-mins using smaller commercial filaments gives rise to uniform lesion volume that together with the improved post-operative care, decreases this model mortality. Furthermore, this allows for intensive long-term functional evaluation of mice. This way, clinical symptoms and ethology, as well as scales used to evaluate stroke, are mimicked in a mouse model.
Subject
Neurology (clinical),Neurology
Cited by
2 articles.
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