Author:
Su Gao-Jian,Zhang Di,Wu Jia-Nuo,Deng Yu-Hang,Wu Chu-Wei,Zhang Xie-Jun,Huang Xian-Jian
Abstract
To determine the possible role of matrix metallopeptidase (MMP)-8 and MMP-9 in the development of chronic subdural hematoma (CSDH), we investigated their expression in CSDH. In our previous study, we analyzed hematoma fluid and peripheral blood of 83 patients with CSDH, including 17 postoperative patients. Based on these results, we included 50 people in the normal group and analyzed 20 markers in the peripheral blood of each person. In order to identify representative markers, it was assessed by using overall differential gene expression. The concentration of MMP-8 was significantly higher in the normal group than that in the preoperative and postoperative groups. The concentration of MMP-9 was significantly lower in the normal group than in both preoperative and postoperative groups. Immunohistochemistry confirmed the expression of MMP-8 and MMP-9 in CSDH membranes. In conclusion, our results provide evidence of the expression of MMP-8 and MMP-9 in CSDH. In addition, the expression of MMP-8 and MMP-9 suggests angiogenesis in CSDH formation.
Subject
Neurology (clinical),Neurology
Reference24 articles.
1. Updates in chronic subdural hematoma: epidemiology, etiology, pathogenesis, treatment, and outcome;Feghali;World Neurosurg.,2020
2. Chronic subdural haematoma: Modern management and emerging therapies;Kolias;Nat Rev Neurol.,2014
3. Drug treatment of chronic subdural hematoma;Huang;Expert Opin Pharmacother.,2020
4. Clinical evolutional aspects of chronic subdural haematomas–Literature review;Iliescu;J Med Life,2015
5. Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy;Edlmann;J Neuroinflammation.,2017
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献