Prediction of Cerebral Amyloid Pathology Based on Plasma Amyloid and Tau Related Markers
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Published:2021-10-04
Issue:
Volume:12
Page:
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ISSN:1664-2295
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Container-title:Frontiers in Neurology
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language:
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Short-container-title:Front. Neurol.
Author:
Chen Ting-Bin,Lin Kun-Ju,Lin Szu-Ying,Lee Yi-Jung,Lin Yi-Cheng,Wang Chen-Yu,Chen Jun-Peng,Wang Pei-Ning
Abstract
Background and Purpose: Pyroglutamate-modified β-amyloid peptide (AβpE) is crucial for AD pathophysiological process. The potential associations of plasma AβpE and total tau (t-tau) with brain Aβ burden and cognitive performance remain to be clarified.Methods: Forty-six subjects with unimpaired cognition, mild cognitive impairment, or very mild dementia were enrolled. Plasma levels of AβpE3−40, t-tau, and Aβ42 were quantified by immunomagnetic reduction (IMR) assays. We analyzed individual and combined biomarker correlations with neuropsychological scores and Aβ positivity determined by 18F-florbetapir positron emission tomography (PET).Results: Both plasma AβpE3−40 levels and AβpE3−40/t-tau ratios correlated negatively with short-term memory and global cognition scores, while correlating positively with PET standardized uptake value ratios (SUVRs). Among the biomarkers analyzed, the combination of AβpE3−40 in a ratio with t-tau had the best discriminatory ability for Aβ PET positivity. Likewise, logistic regression analysis showed that AβpE3−40/t-tau was a highly robust predictor of Aβ PET positivity after controlling for relevant demographic covariates.Conclusion: Plasma AβpE3−40/t-tau ratios correlate with cognitive function and cerebral Aβ burden. The suitability of AβpE3−40/t-tau as a candidate clinical biomarker of AD pathology in the brain should be examined further in larger studies.
Funder
Brain Research Center, National Yang-Ming University
Taipei Veterans General Hospital
Chang Gung Memorial Hospital
Publisher
Frontiers Media SA
Subject
Clinical Neurology,Neurology
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