Author:
Stovell Matthew G.,Helmy Adel,Thelin Eric P.,Jalloh Ibrahim,Hutchinson Peter J.,Carpenter Keri L. H.
Abstract
Cerebral microdialysis may be used in patients with severe brain injury to monitor their cerebral physiology. In this article we provide a concise synopsis with illustrations and original images of catheter types, their structure, and how they function. Where and how catheters are inserted, their identification on imaging modalities (CT and MRI), together with the roles of glucose, lactate/pyruvate ratio, glutamate, glycerol and urea are summarized in acute brain injury. The research applications of microdialysis including pharmacokinetic studies, retromicrodialysis, and its use as a biomarker for efficacy of potential therapies are outlined. Finally, we explore limitations and pitfalls of the technique, as well as potential improvements and future work that is needed to progress and expand the use of this technology.
Funder
Medical Research Council
Royal College of Surgeons of England
NIHR Cambridge Biomedical Research Centre
National Institute for Health and Care Research
Familjen Erling-Perssons Stiftelse
Invention for Innovation
Subject
Neurology (clinical),Neurology
Cited by
1 articles.
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