Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial
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Published:2024-05-09
Issue:
Volume:15
Page:
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ISSN:1664-2295
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Container-title:Frontiers in Neurology
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language:
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Short-container-title:Front. Neurol.
Author:
Cheung Teris,Yee Benjamin K.,Chau Bolton,Lam Joyce Yuen Ting,Fong Kwan Hin,Lo Herman,Li Tim Man Ho,Li Albert Martin,Sun Lei,Beisteiner Roland,Cheng Calvin Pak Wing
Abstract
BackgroundThis is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong.MethodsThis double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyze data.ResultsThe TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups.ConclusionTPS is an effective and safe adjunct treatment for the clinical management of ADHD.Clinical trial registrationClinicalTrials.Gov, identifier NCT05422274.
Publisher
Frontiers Media SA