Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)-Reference-Cited by-同舟云学术

Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)

Published:2021-11-05 Issue: Volume:12 Page:
ISSN:1664-2295
Container-title:Frontiers in Neurology
language:
Short-container-title:Front. Neurol.

Author:

Sitnikova Evgenia

Abstract

Wistar Albino Glaxo Rijswijk (WAG/Rij) rats are widely used in basic and pre-clinical studies as a valid genetic model of absence epilepsy. Adult WAG/Rij rats exhibit generalized 8–10-Hz spike-wave discharges (SWDs) in the electroencephalogram. SWDs are known to result from thalamocortical circuit dysfunction, and this implies an intimate relationship between slow-wave EEG activity, sleep spindles, and SWDs. The present mini review summarizes relevant research on sleep-related disturbances associated with spike-wave epilepsy in WAG/Rij rats in the domain of slow-wave sleep EEG and microarousals. It also discusses enhancement of the intermediate stage of sleep. In general, sleep EEG studies provide important information about epileptogenic processes related to spike-wave epilepsy.

Funder

Russian Foundation for Basic Research

Ministry of Education and Science of the Russian Federation

Publisher

Frontiers Media SA

Subject

Neurology (clinical),Neurology

Reference53 articles.

1. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology;Scheffer;Epilepsia.,2017

2. The current state of absence epilepsy: can we have your attention?;Tenney;Epilepsy Curr,2013

3. Generalized nonmotor (absence) seizures-What do absence, generalized, and nonmotor mean?;Unterberger;Epilepsia,2018

4. Electroencephalographic differences between WAG/Rij and GAERS rat models of absence epilepsy;Akman;Epilepsy Res.,2010

5. Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy;Pearce;Epilepsy Behav.,2014

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