Visually and Tactually Guided Grasps Lead to Different Neuronal Activity in Non-human Primates

Abstract

Movements are defining characteristics of all behaviors. Animals walk around, move their eyes to explore the world or touch structures to learn more about them. So far we only have some basic understanding of how the brain generates movements, especially when we want to understand how different areas of the brain interact with each other. In this study we investigated the influence of sensory object information on grasp planning in four different brain areas involved in vision, touch, movement planning, and movement generation in the parietal, somatosensory, premotor and motor cortex. We trained one monkey to grasp objects that he either saw or touched beforehand while continuously recording neural spiking activity with chronically implanted floating multi-electrode arrays. The animal was instructed to sit in the dark and either look at a shortly illuminated object or reach out and explore the object with his hand in the dark before lifting it up. In a first analysis we confirmed that the animal not only memorizes the object in both tasks, but also applies an object-specific grip type, independent of the sensory modality. In the neuronal population, we found a significant difference in the number of tuned units for sensory modalities during grasp planning that persisted into grasp execution. These differences were sufficient to enable a classifier to decode the object and sensory modality in a single trial exclusively from neural population activity. These results give valuable insights in how different brain areas contribute to the preparation of grasp movement and how different sensory streams can lead to distinct neural activity while still resulting in the same action execution.