Author:
de Paula Gabriela Cristina,Brunetta Henver S.,Engel Daiane F.,Gaspar Joana M.,Velloso Licio A.,Engblom David,de Oliveira Jade,de Bem Andreza Fabro
Abstract
Graphical AbstractAn illustrative scheme summarizing the main outcomes in Swiss mice fed high-fat diet (HFD), with their exact time of onset of changes in the hippocampus. An increase in the expression of proinflammatory cytokines, together with the permeability of the blood–brain barrier was detected after 2 days of HFD. Even in the first week of dietary intervention, memory and learning impairment, depressive-like behavior, and synaptic changes were observed at 3, 5, and 7 days, respectively. Later hippocampal alterations (after 4 weeks of HFD consumption) include mitochondrial dysfunction and astrocytic activation.
Funder
Fundação de Apoio à Pesquisa do Distrito Federal
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação
Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Cited by
49 articles.
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