Author:
Liu Yonghong,Yue Wenji,Yu Shoujun,Zhou Tian,Zhang Yapeng,Zhu Ran,Song Bing,Guo Tianruo,Liu Fenglin,Huang Yubin,Wu Tianzhun,Wang Hao
Abstract
The physical principle of myelin development is obtained from our previous study by explaining Peter’s quadrant mystery: an externally applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath, respectively. In this study, this principle is considered as a fundamental hypothesis, named Hypothesis-E, to explain more phenomena about myelin development systematically. Specifically, the g-ratio and the fate of the Schwann cell’s differentiation are explained in terms of the E-field. Moreover, an experiment is proposed to validate this theory.