Functional Reorganization After Four-Week Brain–Computer Interface-Controlled Supernumerary Robotic Finger Training: A Pilot Study of Longitudinal Resting-State fMRI

Abstract

Humans have long been fascinated by the opportunities afforded through motor augmentation provided by the supernumerary robotic fingers (SRFs) and limbs (SRLs). However, the neuroplasticity mechanism induced by the motor augmentation equipment still needs further investigation. This study focused on the resting-state brain functional reorganization during longitudinal brain–computer interface (BCI)-controlled SRF training in using the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC) metrics. Ten right-handed subjects were enrolled for 4 weeks of BCI-controlled SRF training. The behavioral data and the neurological changes were recorded at baseline, training for 2 weeks, training for 4 weeks immediately after, and 2 weeks after the end of training. One-way repeated-measure ANOVA was used to investigate long-term motor improvement [F(2.805,25.24) = 43.94, p < 0.0001] and neurological changes. The fALFF values were significantly modulated in Cerebelum_6_R and correlated with motor function improvement (r = 0.6887, p < 0.0402) from t0 to t2. Besides, Cerebelum_9_R and Vermis_3 were also significantly modulated and showed different trends in longitudinal SRF training in using ReHo metric. At the same time, ReHo values that changed from t0 to t1 in Vermis_3 was significantly correlated with motor function improvement (r = 0.7038, p < 0.0344). We conclude that the compensation and suppression mechanism of the cerebellum existed during BCI-controlled SRF training, and this current result provided evidence to the neuroplasticity mechanism brought by the BCI-controlled motor-augmentation devices.