Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior-Reference-Cited by-同舟云学术

Negative Modulation of the Metabotropic Glutamate Receptor Type 5 as a Potential Therapeutic Strategy in Obesity and Binge-Like Eating Behavior

Published:2021-02-10 Issue: Volume:15 Page:
ISSN:1662-453X
Container-title:Frontiers in Neuroscience
language:
Short-container-title:Front. Neurosci.

Author:

Oliveira Tadeu P. D.,Gonçalves Bruno D. C.,Oliveira Bruna S.,de Oliveira Antonio Carlos P.,Reis Helton J.,Ferreira Claudia N.,Aguiar Daniele C.,de Miranda Aline S.,Ribeiro Fabiola M.,Vieira Erica M. L.,Palotás András,Vieira Luciene B.

Abstract

Graphical AbstractDiet-induced obese (DIO) C57BL/6 mice were treated for 14 days with VU0409106, a negative allosteric modulator of mGluR5. Food intake, body weight, inflammatory/hormonal levels, and behavioral tests were performed. Our data suggest reduction of feeding, body weight, and adipose tissue inflammation in DIO mice after chronic treatment with VU0409106.

Publisher

Frontiers Media SA

Subject

General Neuroscience

Reference68 articles.

1. A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder.;Arnold;J. Clin. Psychiatry,2002

2. Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway.;Arora;Behav. Brain Res.,2013

3. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking.;Bäckström;Neuropsychopharmacology,2006

4. Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice.;Bake;Appetite,2014

5. Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss.;Barja-Fernandez;Drug Des. Devel. Ther.,2014

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Excessive sucrose consumption reduces synaptic density and increases cannabinoid receptors in Göttingen minipigs;Neuropharmacology;2024-09

2. The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies;Psychopharmacology;2024-07-09

3. Replication Study of Genome Wide Association Study of Sleep Duration in Korean Association Resources Cohort;Biomedical Science Letters;2024-06-30

4. The Emerged Perspective on Obesity Etiology: Metaflammation Induces Food Reward Dysfunction;PROG BIOCHEM BIOPHYS;2024

5. Child eating behavior predicts body mass index after 1 year: results from the Swiss Preschooler’s Health Study (SPLASHY);Frontiers in Psychology;2024-04-02