Accounting for multiscale processing in adaptive real-world decision-making via the hippocampus

Abstract

For adaptive real-time behavior in real-world contexts, the brain needs to allow past information over multiple timescales to influence current processing for making choices that create the best outcome as a person goes about making choices in their everyday life. The neuroeconomics literature on value-based decision-making has formalized such choice through reinforcement learning models for two extreme strategies. These strategies are model-free (MF), which is an automatic, stimulus–response type of action, and model-based (MB), which bases choice on cognitive representations of the world and causal inference on environment-behavior structure. The emphasis of examining the neural substrates of value-based decision making has been on the striatum and prefrontal regions, especially with regards to the “here and now” decision-making. Yet, such a dichotomy does not embrace all the dynamic complexity involved. In addition, despite robust research on the role of the hippocampus in memory and spatial learning, its contribution to value-based decision making is just starting to be explored. This paper aims to better appreciate the role of the hippocampus in decision-making and advance the successor representation (SR) as a candidate mechanism for encoding state representations in the hippocampus, separate from reward representations. To this end, we review research that relates hippocampal sequences to SR models showing that the implementation of such sequences in reinforcement learning agents improves their performance. This also enables the agents to perform multiscale temporal processing in a biologically plausible manner. Altogether, we articulate a framework to advance current striatal and prefrontal-focused decision making to better account for multiscale mechanisms underlying various real-world time-related concepts such as the self that cumulates over a person’s life course.