Author:
Ren Yuan,Qiu Zi-Han,Wu Wei-Hua,Dong Xiao-Guang,Han Shuang,Zhang Fu-Liang,Kong Fan-Li,Li Feng-E
Abstract
ObjectiveTo explore the relationship of hypertriglyceridemic waist phenotype (HTWP) with initial neurological severity and etiologic subtypes in patients with acute ischemic stroke.MethodsThe data for this study were collected from hospitalized patients within 72 h of acute ischemic stroke onset at the Department of Neurology of the Affiliated Hospital of Beihua University from 1 July 2020 to 30 June 2022. The initial neurological severity was assessed by the National Institute of Health Stroke Scale (NIHSS) on the day of admission: NIHSS <6 was defined as mild stroke, and NIHSS ≥6 as moderate to severe stroke. HTWP was defined by fasting serum triglycerides ≥1.7 mmol/L and waist circumference ≥90 cm in men and ≥80 cm in women. Differentiation of etiologic subtypes was based on the method reported in the Trial of Org 10 172 in Acute Stroke Treatment. Multivariate logistic regression analysis was used to analyze the association of HTWP with initial neurological severity and etiologic subtypes.ResultsThe study included 431 patients. Compared with the normal waist–normal blood triglyceride group, patients with HTWP had reduced risks of moderate to severe stroke [odds ratio (OR): 0.384, 95% confidence interval (CI): 0.170–0.869; P = 0.022]. In addition, the risk of small-artery occlusion stroke was 2.318 times higher in the HTWP group than in the normal triglyceride–normal waist (NWNT) group (OR: 2.318, 95% CI: 1.244–4.319; P = 0.008).ConclusionInitial neurological severity was less severe in patients with HTWP, and HTWP was associated with an increased risk of small-artery occlusion stroke.
Subject
Endocrinology, Diabetes and Metabolism
Reference53 articles.
1. Global burden of cardiovascular diseases and risk factors, 1990-2019: Update from the GBD 2019 study;Roth;J Am Coll Cardiol,2020
2. Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the global burden of disease study 2017;Zhou;Lancet,2019
3. Prevalence, incidence, and mortality of stroke in China: Results from a nationwide population-based survey of 480 687 adults;Wang;Circulation,2017
4. Thrombolysis for acute ischaemic stroke;Wardlaw;Cochrane Database Syst Rev,2014
5. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials;Goyal;Lancet,2016