Author:
Xing Yuan,Ye Yumeng,Zuo Hongyan,Li Yang
Abstract
Thymosin β4 (Tβ4) is a multifunctional and widely distributed peptide that plays a pivotal role in several physiological and pathological processes in the body, namely, increasing angiogenesis and proliferation and inhibiting apoptosis and inflammation. Moreover, Tβ4 is effectively utilized for several indications in animal experiments or clinical trials, such as myocardial infarction and myocardial ischemia-reperfusion injury, xerophthalmia, liver and renal fibrosis, ulcerative colitis and colon cancer, and skin trauma. Recent studies have reported the potential application of Tβ4 and its underlying mechanisms. The present study reveals the progress regarding functions and applications of Tβ4.
Funder
National Major Science and Technology Projects of China
Subject
Endocrinology, Diabetes and Metabolism
Reference133 articles.
1. Acceleration by Thymosin of the Development of Resistance to Murine Sarcoma Virus-Induced Tumor in Mice;Zisblatt;Proc Natl Acad Sci USA,1970
2. Beta-Thymosins, Small Acidic Peptides With Multiple Functions;Huff;Int J Biochem Cell Biol,2001
3. The Thymosins. Prothymosin Alpha, Parathymosin, and Beta-Thymosins: Structure and Function;Hannappel;Vitam Horm,2003
4. Thymosin β4: Actin-Sequestering Protein Moonlights to Repair Injured Tissues;Goldstein;Trends Mol Med,2005
5. Preparation, Assay, and Partial Purification of a Thymic Lymphocytopoietic Factor (Thymosin);Goldstein;Proc Natl Acad Sci USA,1966
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