Author:
Liśkiewicz Arkadiusz D.,Marczak Łukasz,Bogus Katarzyna,Liśkiewicz Daniela,Przybyła Marta,Lewin-Kowalik Joanna
Abstract
Obesity cardiomyopathy increases the risk of heart failure and death. Obesity is curable, leading to the restoration of the heart phenotype, but it is not clear if there are any after-effects of obesity present after weight loss. We characterize the proteomic landscape of obesity cardiomyopathy with an evaluation of whether the cardiac phenotype is still shaped after weight loss. Cardiomyopathy was validated by cardiac hypertrophy, fibrosis, oversized myocytes, and mTOR upregulation in a rat model of cafeteria diet-induced developmental obesity. By global proteomic techniques (LC-MS/MS) a plethora of molecular changes was observed in the heart and circulation of obese animals, suggesting abnormal utilization of metabolic substrates. This was confirmed by increased levels of cardiac ACSL-1, a key enzyme for fatty acid degradation and decreased GLUT-1, a glucose transporter in obese rats. Calorie restriction and weight loss led to the normalization of the heart’s size, but fibrosis was still excessive. The proteomic compositions of cardiac tissue and plasma were different after weight loss as compared to control. In addition to morphological consequences, obesity cardiomyopathy involves many proteomic changes. Weight loss provides for a partial repair of the heart’s architecture, but the trace of fibrotic deposition and proteomic alterations may occur.
Funder
Nutricia Research Foundation
Śląski Uniwersytet Medyczny
Subject
Endocrinology, Diabetes and Metabolism
Reference110 articles.
1. The obesity pandemic: where have we been and where are we going;Roth;Obes Res,2004
2. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults;Lancet (London England),2017
3. Prevalence of Obesity and Severe Obesity in US Children, 1999-2016;Skinner;Pediatrics,2018
4. The Science of Obesity Management: An Endocrine Society Scientific Statement;Bray;Endocr Rev,2018
5. The medical risks of obesity;Pi-Sunyer;Postgrad Med,2009
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