Author:
He Zhongrong,Lv Yanyun,Zheng Suijin,Pu Yudong,Lin Qingmei,Zhou He,Dong Moran,Wang Jiaqi,Fan Jingjie,Ye Yufeng,Chen Hanwei,Qian Rui,Jin Juan,Chen Yumeng,Chen Guimin,He Guanhao,Cheng Shouzhen,Hu Jianxiong,Xiao Jianpeng,Ma Wenjun,Su Xi,Liu Tao
Abstract
ImportanceThe ongoing pandemic of COVID-19 is still affecting our life, but the effects of lockdown measures on gestational diabetes mellitus (GDM) in pregnant women remain unclear.AimTo investigate the association between COVID-19 lockdown and GDM.Subjects and MethodsMedical records of 140844 pregnant women during 2015-2020 were extracted from 5 hospitals in Guangdong Province, China. Pregnant women who underwent the COVID-19 Level I lockdown (1/23 - 2/24/2020) during pregnancy were defined as the exposed group (N=20472) and pregnant women who underwent the same calendar months during 2015-2019 (1/23 - 2/24) were defined as the unexposed group (N=120372). Subgroup analyses were used to explore the potential susceptible exposure window of COVID-19 lockdown on GDM. Cumulative exposure is quantitatively estimated by assigning different weights to response periods with different exposure intensities. A logistic regression model was used to estimate the association between COVID-19 lockdown exposure and GDM.ResultsThe rates of GDM in the exposed and unexposed groups were 15.2% and 12.4%, respectively. The overall analyses showed positive associations (odds ratio, OR=1.22, 95%CI: 1.17, 1.27) between lockdown exposure and GDM risk in all pregnant women. More pronounced associations were found in women who underwent the COVID-19 lockdown in their first four months of pregnancy, and the adjusted OR values ranged from 1.24 (95%CI: 1.10, 1.39) in women with 5-8 gestational weeks (GWs) to 1.35 (95%CI: 1.20, 1.52) with < 5 GWs. In addition, we found a positive exposure-response association of cumulative lockdown exposure with the risk of GDM.ConclusionsThe COVID-19 lockdown was associated with an increased risk of GDM, and the first four months of pregnancy may be the window for sensitive exposure.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Science and Technology Planning Project of Guangdong Province
Chuzhou Science and Technology Program
Subject
Endocrinology, Diabetes and Metabolism
Cited by
9 articles.
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