Author:
Fusco Ferdinando,Longo Nicola,De Sio Marco,Arcaniolo Davide,Celentano Giuseppe,Capece Marco,La Rocca Roberto,Mangiapia Francesco,Califano Gianluigi,Morra Simone,Turco Carmine,Spena Gianluca,Spirito Lorenzo,Fusco Giovanni Maria,Cirillo Luigi,De Luca Luigi,Napolitano Luigi,Mirone Vincenzo,Creta Massimiliano
Abstract
The purpose of this mini review is to provide data about pre-clinical and clinical evidence exploring the impact of circadian desynchrony on spermatogenesis. Several lines of evidence exist demonstrating that disruption of circadian rhythms may interfere with male fertility. Experimental knock-out or knock-down of clock genes, physiologically involved in the regulation of circadian rhythms, are associated with impairments of fertility pathways in both animal and human models. Moreover, disruption of circadian rhythms, due to reduction of sleep duration and/or alteration of its architecture can negatively interfere in humans with circulating levels of male sexual hormones as well as with semen parameters. Unfortunately, current evidence remains low due to study heterogeneity.
Subject
Endocrinology, Diabetes and Metabolism
Cited by
9 articles.
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