Abnormal glucose homeostasis and fasting intolerance in patients with congenital porto-systemic shunts

Author:

van Albada Mirjam E.,Shah Pratik,Derks Terry G. J.,Fuchs Sabine,Jans Judith J. M.,McLin Valérie,van der Doef Hubert P. J.

Abstract

In physiological glucose homeostasis, the liver plays a crucial role in the extraction of glucose from the portal circulation and storage as glycogen to enable release through glycogenolysis upon fasting. In addition, insulin secreted by the pancreas is partly eliminated from the systemic circulation by hepatic first-pass. Therefore, patients with a congenital porto-systemic shunt present a unique combination of (a) postabsorptive hyperinsulinemic hypoglycaemia (HH) because of decreased insulin elimination and (b) fasting (ketotic) hypoglycaemia because of decreased glycogenolysis. Patients with porto-systemic shunts therefore provide important insight into the role of the portal circulation and hepatic function in different phases of glucose homeostasis.

Publisher

Frontiers Media SA

Subject

Endocrinology, Diabetes and Metabolism

Reference39 articles.

1. Newly discovered endocrine functions of the liver;Rhyu;World J Hepatol,2021

2. Regulation of hepatic blood flow: the hepatic arterial buffer response revisited;Eipel;World J Gastroenterol,2010

3. Premature pubarche, hyperinsulinemia and hypothyroxinemia: novel manifestations of congenital portosystemic shunts (Abernethy malformation) in children;Bas;Horm Res Paediatr,2015

4. An overview of hypoglycemia in children including a comprehensive practical diagnostic flowchart for clinical use;Casertano;Front Endocrinol (Lausanne),2021

5. Congenital intrahepatic portacaval anastomosis: analysis of manifested glucose abnorMalities;Gouin;Gastroenterol Clin Biol,1984

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