Author:
Drabsch Theresa,Junker Daniela,Bayer Sandra,Wu Mingming,Held Cora,Karampinos Dimitrios C.,Hauner Hans,Holzapfel Christina
Abstract
BackgroundThe difference of proton density fat fraction (PDFF) between supraclavicular and gluteal adipose tissue might indicate the presence of brown adipose tissue (BAT). Aim of this cross-sectional study was to investigate the association between PDFF over the supraclavicular fat region as a proxy of BAT proportion and resting metabolic rate (RMR). In addition, the association between the single nucleotide polymorphism (SNP) rs1421085 at the fat mass and obesity associated (FTO) gene locus and both PDFF and RMR was investigated.MethodsAnthropometric, clinical, and lifestyle data from 92 healthy adults (66.3% females, mean age: 36.2 ± 13.0 years, mean body mass index: 24.9 ± 5.4 kg/m2) were included in the analysis. The RMR was measured by indirect calorimetry. The magnetic resonance imaging (MRI) was used for the measurement of visceral and subcutaneous adipose tissue (VAT, SAT) volumes and for the measurement of adipose tissue PDFF.ResultsMean RMR of the whole group was 1 474.8 ± 242.2 kcal. Genotype data was available for 90 participants. After adjustment for age, sex, weight change and fat-free mass (FFM), no association was found between supraclavicular PDFF (p = 0.346) and gluteal PDFF (p = 0.252), respectively, and RMR, whereas statistically significant evidence for a negative association between delta PDFF (difference between gluteal PDFF and supraclavicular PDFF) and RMR (p = 0.027) was obtained. No statistically significant evidence was observed for per FTO risk allele change in RMR, gluteal and supraclavicular PDFF maps or volumes of VAT and SAT.ConclusionsSupraclavicular PDFF as a surrogate marker of BAT presence is not a determinant of RMR under basal conditions. In the present study, the FTO rs1421085 variant is not associated with either RMR or PDFF. Further studies are needed to elucidate the effect of BAT on RMR.
Subject
Endocrinology, Diabetes and Metabolism
Reference41 articles.
1. Factors Influencing Variation in Basal Metabolic Rate Include Fat-Free Mass, Fat Mass, Age, and Circulating Thyroxine But Not Sex, Circulating Leptin, or Triiodothyronine;Johnstone;Am J Clin Nutr,2005
2. Gender Differences in Resting Metabolic Rate and Noradrenaline Kinetics in Older Individuals;Poehlman;Eur J Clin Invest,1997
3. Relationship of Genetics, Age, and Physical Fitness to Daily Energy Expenditure and Fuel Utilization;Ravussin;Am J Clin Nutr,1989
4. Metabolically Active Components of Fat-Free Mass and Resting Energy Expenditure in Humans: Recent Lessons From Imaging Technologies;Muller;Obes Rev,2002
5. Determinants of Energy Expenditure and Fuel Utilization in Man: Effects of Body Composition, Age, Sex, Ethnicity and Glucose Tolerance in 916 Subjects;Weyer;Int J Obes Relat Metab Disord,1999
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献