Author:
Barredo Celia G.,Gil-Marti Beatriz,Deveci Derya,Romero Nuria M.,Martin Francisco A.
Abstract
Puberty and metamorphosis are two major developmental transitions linked to the reproductive maturation. In mammals and vertebrates, the central brain acts as a gatekeeper, timing the developmental transition through the activation of a neuroendocrine circuitry. In addition to reproduction, these neuroendocrine axes and the sustaining genetic network play additional roles in metabolism, sleep and behavior. Although neurohormonal axes regulating juvenile-adult transition have been classically considered the result of convergent evolution (i.e., analogous) between mammals and insects, recent findings challenge this idea, suggesting that at least some neuroendocrine circuits might be present in the common bilaterian ancestor Urbilateria. The initial signaling pathways that trigger the transition in different species appear to be of a single evolutionary origin and, consequently, many of the resulting functions are conserved with a few other molecular players being co-opted during evolution.
Funder
Ministerio de Ciencia e Innovación
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas
Institut National de la Santé et de la Recherche Médicale
Agence Nationale de la Recherche
Subject
Endocrinology, Diabetes and Metabolism
Cited by
4 articles.
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