Is the METS-IR Index a Potential New Biomarker for Kidney Stone Development?

Author:

Shen Xudong,Chen Yang,Chen Yan,Liang Hu,Li Guoxiang,Hao Zongyao

Abstract

ObjectiveThe purpose of this study was to examine whether the METS-IR index is associated with kidney stones in American adults.MethodParticipants from the National Health and Nutrition Examination Survey (NHANES) database from 2007-2018 were selected for logistic regression analysis, subgroup analyses, and the calculation of dose-response curves to assess the association between the METS-IR index and the incidence of kidney stones.ResultThis study enrolled 30,612 adults aged >20 years, 2901 of whom self-reported having had kidney stones in the past. And, after controlling for potential confounders, each unit increase in the METS-IR index was linked with a 1.23 percent rise in kidney stone incidence (OR= 1.0123, 95% CI: 1.0092 - 1.0155), with stratified analysis indicating that this was true in all subgroups. Between all groups, an elevated METS-IR index was related to kidney stone formation, and the dose-response curve revealed a positive non-linear connection between METS-IR index and kidney stone risk, with a threshold effect analysis revealing an inflection point value of 50.8314.ConclusionHigher METS-IR index is associated with the occurrence of kidney stones,and while no causative association can be shown, this is cause for concern.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Anhui Province

Publisher

Frontiers Media SA

Subject

Endocrinology, Diabetes and Metabolism

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