Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure

Author:

Keitel Verena,Bode Johannes Georg,Feldt Torsten,Walker Andreas,Müller Lisa,Kunstein Anselm,Klindt Caroline,Killer Alexander,Senff Tina,Timm Jörg,Ostermann Philipp,Damagnez Maximilian,Lübke Nadine,Adams Ortwin,Schaal Heiner,Antoch Gerald,Neubert Jennifer,Albrecht Philipp,Meuth Sven,Elben Saskia,Mohring Annemarie,Fischer Johannes C.,Bölke Edwin,Hoenig Manfred,Schulz Ansgar S.,Luedde Tom,Jensen Björn

Abstract

We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune response for SARS-CoV-2 clearance.

Publisher

Frontiers Media SA

Subject

Immunology,Immunology and Allergy

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